| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59c6a921f33fe0adc58c2b6177184515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d16462827491197ea8208881ec81e36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca62f4a5bcad48cdfe34effb0023af0a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2510-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1761
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2001-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0f951bd0a5623511cc19a16cd52a45f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f3acf6f117161dab240be67923ed763 |
| publicationDate |
2002-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0203921-A2 |
| titleOfInvention |
Bax fragment induced tumor cell death |
| abstract |
The present inventio relats treatment of tumors using a Bax protein fragment to induce apoptosis. More specifically, the present invention relates to the use of the Bax amino terminus 18kDa fragment to induce cytochrome c release and apoptosis in cancer cells. Further provided is the method of inducing cell death even in cancer cells overexpressing Bcl-2 oncoprotein. Further provided is a method using Bax/p18 of triggering cytochrome c release, activation of caspase-3, cleavage of poly(ADP-ribose) polymerase, fragmentation of DNA and induction of cell death. Further provided is a method of introducing Bax/p18 protein into a cancer cell via introducing Bax/p18 cDNA, to cause release of cytochrome c and induction of caspase-3 mediated apoptosis that is not blocked by overexpression of Bcl-2. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1551990-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1551990-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102226186-A |
| priorityDate |
2000-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |