| abstract |
The present invention concerns a process for modulating the function of a DNA element in a eukaryotic cell, comprising the step of contacting a genomic DNA element, so-called 'chromatin responsive element' (CRE), with a compound having a molecular weight of less than approximately 5 KDa, and having the capacity to bind a sequence-specific manner to said CRE, said step of contacting being carried out in conditions permitting chromatin remodeling of the CRE by said compound, wherein said chromatin remodeling of the CRE alters the activity of one or more other DNA elements, so called 'modulated DNA elements' in the genome. |