| abstract |
A remedy for anxiety neurosis or depression which contains an MC4 receptor antagonist as the active ingredient; and a piperazine derivative represented by the formula [1] or a pharmaceutically acceptable salt thereof, wherein Ar1 represents (un)substituted phenyl, etc.; Ar2 represents (un)substituted naphthyl, quinolyl, a group represented by the formula [a] (wherein R4 is hydrogen or halogeno; and X-Y is CH-NH, CH-O, CH-S, or N-O), or a group represented by the formula [b] (wherein R5 is hydrogen, hydroxy, or C¿1-10? alkoxy); R?1¿ represents hydrogen, C¿1-10? alkyl, etc.; R?2 and R3¿ are the same or different and each is hydrogen or C¿1-10? alkyl; A-B represents N-CH2, CH-CH2, C(OH)-CH2, or C=CH; T?1¿ represents a single bond, -O-, etc.; and n is an integer of 1 to 10. |