| abstract |
The invention provides isolated nucleic acid molecules, designated LSO nucleic acid molecules, which encode novel LSO-related lysyl oxidase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing LSO nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an LSO gene has been introduced or disrupted. The invention still further provides isolated LSO proteins, fusion proteins, antigenic peptides and anti-LSO antibodies. Diagnostic methods utilizing compositions of the invention are also provided. |