| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4ab04728c0efc6b42cca66ddef95352c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9c7c3a9423077fcc1ad88cfeb92703e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d735ee72273ae5c463ec92eff37287a9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_19bd06288632de90ceeb6e8a4a4c5c44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7641467e74b2b5e8fb2f4c28507f235
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ccbf450e9f76f8bbfd59f191b4cdcd65 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10243
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2810-405
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2810-6018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 |
| filingDate |
2001-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29de1483adfb492faf1fd95ad8870317
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bfad7058598acadbc1d7f5bcce2bba5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a920891761f14894246e9f8b1934eceb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8959fe3367353fcf5af5c0e51fdb64e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4853fdf05037c34d2d2eac46d3a7e882 |
| publicationDate |
2001-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0192299-A2 |
| titleOfInvention |
Adenovirus particles with mutagenized fiber proteins |
| abstract |
This invention relates to mutated adenoviral fiber proteins and adenovirus particles containing such proteins. It further relates to polynucleotides encoding the proteins and vectors containing polynucleotides. It also relates to methods for making and using the adenoviral particles. With the mutated fiber proteins, the adenovirus particles no longer bind to their natural cellular receptor. They can then be "retargeted" to a specific cell type through the addition of a ligand to the virus capsid, which causes the virus to bind to and infect such cell. Specific fiber mutations are listed, which ablate binding to the natural receptor. Adenovirus particles with certain fiber mutations were found to enhance gene transfer to and expression in liver as compared to viral particles with wild-type fiber. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2856928-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7611868-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005012536-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7473418-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005005467-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005005467-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7232899-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1662004-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1662004-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7858083-B2 |
| priorityDate |
2000-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |