| abstract |
Novel substituted phenylpropionic acid derivatives of the general formula (1), which bind to human peroxisome proliferator activated receptor α (PPARα) as ligand to activate the receptor and thereby exhibit a potent lipid-decreasing effect; and use thereof as drugs: (1) wherein R1 is lower alkyl, lower alkoxy, trifluoromethyl, trifluoromethoxy, optionally substituted phenyl, optionally substituted phenoxy, or optionally substituted benzyloxy; R2 is hydrogen, lower alkyl, or lower alkoxy; R3 is lower alkoxy; and A is -CH¿2?CONH-, -NHCOCH2-, -CH2CH2CO-, CH2CH2CH2-, -CH2CH2O-, -CONHCH2-, -CH2NHCH2-, -COCH2O-, -OCH2CO-, -COCH2NH-, or NHCH2CO-. |