| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45b6e842af2ff4e7797752062b1f9bac |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-3094
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-30677
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-2817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-30756 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3625
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-507
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-2415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-2412
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3691
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3641
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3687 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N1-00 |
| filingDate |
2001-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_945bd302296cc4de1e3d9de4ef0ae1c4 |
| publicationDate |
2001-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0191671-A1 |
| titleOfInvention |
Xenograft heart valves |
| abstract |
The invention provides an article of manufacture comprising a substantially non-immunogenic heart valve xenograft for implantation into humans. The invention further provides methods for preparing a heart valve xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; treating the xenograft with crosslinking agents, and digesting the xenograft with a proteoglycan-depleting factor and/or glycosidase. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a heart valve xenograft for implantation into a human including a portion of a heart valve from a non-human animal, wherein the portion has extracellular components and substantially only dead cells. The extracellular components have reduced proteoglycan molecules. Each of the xenografts of the invention is substantially non-immunogenic and has substantially the same mechanical properties as a corresponding native heart valve. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105854083-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9211361-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103491986-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2433492-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10940184-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11724004-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102263617-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11110201-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1734828-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9592254-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8137411-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012149253-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102080371-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3789047-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10307510-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9238793-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1734828-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103491986-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210008145-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200049890-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9206442-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102203782-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3473278-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2012249538-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2639477-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10413634-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9957477-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10568988-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9956316-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018200162-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200019265-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10207025-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160053972-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10814033-B2 |
| priorityDate |
2000-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |