| abstract |
The invention provides isolated nucleic acid molecules, designated CAH nucleic acid molecules, which encode novel CAH-related carbonic anhydrase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CAH nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CAH gene has been introduced or disrupted. The invention still further provides isolated CAH proteins, fusion proteins, antigenic peptides and anti-CAH antibodies. Diagnostic methods utilizing compositions of the invention are also provided. |