http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0190141-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b0dcedd9a82915796532773b7bd734a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3899a93c972ce60b070fca823112248 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70571 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate | 2001-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_322aff94ab69b9ed3ab203be360b52ee |
| publicationDate | 2001-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-0190141-A2 |
| titleOfInvention | Gb1c isoform and nucleotides |
| abstract | A new human isoform of the gamma-aminobutyric acid receptor gb1c, termed Gb1c, is described as well as nucleic acids encoding same and various assays employing said receptor. The novel Gb1c cDNA encodes a protein of 899 amino acids differering from the previously noted gb1c sequence (Genbank Accession No. AJ012187) by a single amino acid substitution (a glutamine in place of a histidine at position 21). This single amino acid substitution affords the receptor higher affinity for GABAB-selective antagonists. Accordingly, the disclosed Gb1c receptor can be used to differentially screen for GABAB receptor modulators such as agonists or antagonists for the treatment of various CNS disorders, drug addiction, neuropathic pain and gastroesophageal reflux and incontinence. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1642573-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7812026-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03090731-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7718686-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7745474-B2 |
| priorityDate | 2000-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 344.