| abstract |
The present invention features methods of inhibiting tumor growth and/or tumor metastasis in a subject, and methods of treating cancer and/or increasing survival of a subject with a tumor, by inhibiting MCP-1 activity in the subject. The present invention also features methods of identifying a compound that inhibits tumor growth or metastasis, by exposing a sample including an MCP-1 polypeptide, an MCP-1 nucleic acid, an MCP-1 receptor polypeptide, or an MCP-1 receptor nucleic acid to a test compound, and detecting a decrease in MCP-1 activity in the sample, wherein a decrease in MCP-1 activity in the sample identifies a compound that inhibits tumor growth or tumor metastasis. |