| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37baec45ee3bdf82463b00ae3ac17f8d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52a24331fe7882d8a0801155df05d542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e5fd5cc9eaa663712543c310a0fae05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e827b6721c477dc66c1fe3c2e87bcb37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8819a4a421dd58412b59cde54faf5840
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f1be002e605f5334a88660da8757fa7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eeba7f21a03db561c756b5db1ccf5132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ff352b4f272e0b9ebec3727dc595590 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-815 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-815 |
| filingDate |
2000-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_613947ed6fd3fcd9a006dbf99baead04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1efdbf7c0409a63b5cc11e178fafaf2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c3feb79a3a9808b1a077bf74633dc97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7701d936ccc47c70ad8b8dea931c46fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a342d4a8f2e5f69619c86a28293c6103
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93bfa664708c9c36a5532e26fab57481
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e634480e7661d9169f86fbd2138075a |
| publicationDate |
2001-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0185794-A1 |
| titleOfInvention |
Method of preparation for recombinant guamerin and pharmaceutical compositions containing the recombinant guamerin for wound healing |
| abstract |
The present invention relates to a method of preparation for recombinant Guamerin which is effective for wound healing and pharmaceutical compositions containing the recombinant Guamerin. Particulary, the present invention relates to the method of preparation for recombinant Guamerin showing an elastase-inhibiting activity that the recombinant Guamerin is expressed in recombinant Pichia pastoris with AOX1 promoter controlled by methanol. In order to induce the expression of the recombinant Guamerin, the present inventors develops DO (dissolved oxygen)-stat fed-batch culture with an automatic feed-back methanol feeding rate control system. The recombinant Guamerin prepared by the method of the present invention inhibits chemostasis of phagocytes as an elastase inhibitor, so the pharmaceutical compositions containing the recombinant Guamerin are effectively used as a therapeutic agent for wound healing. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100365533-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106916911-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106916911-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110684680-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110684680-B |
| priorityDate |
2000-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |