| abstract |
A compound, which can show potent anti-viral activity against, for example, cytomegalo virus, has the formula (I), wherein R is selected from the group comprising, optionally substituted, C5 to C20 alkyl and, optionally substituted, C5 to C20 cycloalkyl; R' is selected from the group comprising hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, alkyl; R' is selected from the group comprising hydrogen, alkyl, cycloalkyl, halogens, alkyloxy, aryloxy and aryl; Q is selected from the group comprising O, NH, S, N-alkyl and CY2, where Y may be the same or different and is selected from H, alkyl and halogens; X is selected from the group comprising O, NH, S, Se, N-alkyl, (CH2)n where n is 1 to 10, and CY2 where Y may be the same or different and is selected from hydrogen, alkyl and halogens; Z is selected from the group comprising O, S, NH, and N-alkyl; T is selected from the group comprising H, halogens, alkyl (C1 to C10), O-alkyl (C1 to C10), N3 and CN; T' is selected from the group comprising H, halogens, O-alkyl (C1 to C10), N3 and CN; or T and T' together form a bridge which is selected from the group comprising -O-, -NH- and -(CH2)p- wherein p is an integer from 1 to 6; T' is selected from the group comprising H, OH, halogens, N3 and CN; T''' is selected from the group comprising H, OH, halogens, N3 and CN; or T' and T''' together form a bridge which is selected from the group comprising -O-, -NH- and -(CH2)p- wherein p is an integer from 1 to 6; or T and T''' together form =CH2; and W is selected from the group comprising H, a phosphate group a phosphonate group; and a pharmacologically acceptable salt, derivative or pro-drug thereof. |