http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0181561-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ffcb323f734a4c5d144b2871c6766de http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bf333e4fc2ddf96d6d6077f516f8830e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C307-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C307-06 |
| filingDate | 2001-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bf96f456f429470efea5197a2758c9f |
| publicationDate | 2001-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-0181561-A1 |
| titleOfInvention | Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes |
| abstract | Compounds of the general formula (I) are provided, and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or Ri capable of binding at a primary specificity site of a protease; Y is a chemical species reactive to a specific class of protease; each of R2, R3, R5 and R7 is independently selected from the group consisting of hydrogen, alkyls, aryls, substituted aryls, alkylaryls and arylalkyls; R4 and R6 are independently selected from the group consisting of: (a) H, alkyl, aryl, arylalkyl, alkylaryl, substituted derivatives thereof, and Ri; (b) --C(O)OH and derivatives thereof, said derivatives selected from the group consisting of --C(O)OQ, --C(O)NRYRZ, --C(O)[NHCHRi(q)C(O)]qOQ, and --C(O)[NHCHRi(q)C(O)]qNRYRZ; and (c) --CHRiNH2 and derivatives thereof, said derivatives selected from the group consisting of --CHRiNHW, --CHRiNHC(O)OQ, --CHRiNHC(O)R, --CHRiNHC(O)NRYRZ, --CHRiNHC(O)[NHCHRi(q)C(O)]qOQ, --CHRiNHSO2R, and --CHRiNH[C(O)CHRi(r)NH]rW, where q and r independently are integers from 1 to 10 inclusive; J is a carboxyl protecting group; G is an amino protecting group; Q is H, R or J; W is H, R or G; each Ri is independently selected from naturally or non-naturally occurring amino acid side chains; R is alkyl, aryl, substituted aryl, alkylaryl, arylalkyl, or heterocyclic radical; and each RY and RZ is independently H, alkyl, aryl, substituted aryl, alkylaryl, arylalkyl, or heterocyclic radical. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116334049-A |
| priorityDate | 2000-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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