| abstract |
The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N-acetylglucosaminyl-β-(1,4)-N-acetylmuramylmonopeptide and derivatives thereof. The glycopeptide is useful for the preparation of N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and related compounds having a glucosaminyl-β-(1,4)-N-acetylmuramic acid disaccharide core. |