http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0178790-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d75dcf19089085c30cfd48816e07f73c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef01c08c894374995b4f8dc60ae15e92 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70571 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate | 2001-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03abaf83f0849224531e25a71fd2fa3d |
| publicationDate | 2001-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-0178790-A2 |
| titleOfInvention | GENE THERAPHY FOR PULMONARY EDEMA USING ADENOVIRUS VECTORS ENCODING A β2ADRENERGIC RECEPTOR GENE |
| abstract | Methods and compositions are provided for gene therapy for pulmonary edema by the transfer of a human β2AR gene to lung epithelical cells for the purpose of improving responsiveness to endogenous catecholamines and increasing active Na+ transport and pulmonary edema clearance in vivo. Recombinant adenoviral vectors mediate the transfer of the β¿2?AR gene into lung epithelial cells. The vectors employ expression control sequences consisting of viral derived promoter elements linked to cDNAs that express a human β2AR genes. This gene has been shown to be capable of augmenting the function of transport proteins that generate the transepithelial osmotic gradient responsible for the movement of water across epithelial membranes to increase pulmonary edema clearance in mammalian lungs. |
| priorityDate | 2000-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 441.