| abstract |
Time-release coated solid compositions which are hydrogel-forming coated solid preparations composed of a tablet core containing a drug, a hydrogel-forming polymer and a hydrophilic base characterized by (1) the tablet core containing a drug and a highly erodible filler, (2) the erosion ratio of the tablet core ranging from about 40 to about 90%, and (3) the outer layer being substantially free from the same drug as the above-described drug. The drug is released after a definite time lag, which enables efficient drug delivery to a specific site in the digestive tract. Therefore, these preparations are useful in the oral administration of drugs considered as exerting the efficacy when delivered to a disease site in the lower part of the digestive tract at a high concentration, drugs considered as being efficacious when absorbed in the lower part of the digestive tract, drugs being efficacious in time-scheduled drug therapy, etc. |