| abstract |
The present invention relates to compositions and methods for the treatment and diagnosis of conditions, disorders, or diseases involving cell death. The invention encompasses protective nucleic acids which, when introduced into a cell predisposed to undergo cell death or in the process of undergoing cell death, prevent, delay, or rescue said cell from death relative to a corresponding cell into which no exogenous nucleic acids have been introduced. The invention encompasses nucleic acids of the protective sequence, host cell expression systems of the protective sequence, hosts that have been transformed by these expression systems, including transgenic animals. The invention also encompasses protective sequence products, including proteins, polypeptides, peptides, fusion proteins, antibodies, antisense molecules or sequence, ribozyme molecules, and inhibitors or modulators directed against such protective sequences, protective sequence products, genes, gene products, and/or their regulatory elements involved in cell death. |