| abstract |
Compounds of formula (1) are described, wherein R1 represents an aryl or heteroaryl group; A, B, D and E, which may be the same or different, each represents a nitrogen atom or a C(R2) group [in which R2 is a hydrogen or halogen atom or an alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxy, -NO¿2? or -CN group] provided that two or more of A, B, D and E are C(R?2¿) groups; X represents an oxygen or sulphur atom or a N(R3) group in which R3 is a hydrogen atom or an alkyl group; Q, R, S and T, which may be the same or different each represents a nitrogen atom or a group C(R4) [in which R4 is an atom or group -L1(Alk1)rL2(R5)S], provided that two or more of Q, R, S and T are C(R4) groups. The compounds are potent and selective inhibitors of the enzyme phosphodiesterase 7 and are of use in the treatment of autoimmune and other diseases in which inhibition of the enzyme can have a beneficial effect. |