| abstract |
The present invention provides methods and compositions for screening, diagnosis and prognosis of Vascular Dementia, for monitoring the effectiveness of Vascular Dementia treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. Vascular Dementia-Associated Features (VFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Vascular Dementia-Associated Protein Isoforms (VPIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated VPIs, antibodies immunospecific for VPIs, and kits comprising the aforesaid. |