| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f49294b4a6cb3047ba52c91ea758d7c2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec3d7a9a543c4214ef75cdabb2d0e04b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c97bc8e7f35fbff547823f43268005be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-522 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-28 |
| filingDate |
2001-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2f7afc82182df92be96f4424689eeb5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1813831f2c03886dfe73b8a2c45cd5c3 |
| publicationDate |
2001-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0168829-A2 |
| titleOfInvention |
Genetically stable cholera vaccines |
| abstract |
The invention relates to nontoxigenic genetically stable mutant strains of Vibrio cholerae which lack functional flagellum and are useful as a vaccine for inducing immunological protection against cholera and a method for making the same. The strains of the present invention comprise a genetically engineered deletion mutation resulting in loss of at least part of a gene encoding a protein required for the energization or assembly of flagellum. In particular, mutant strains lacking one or more functional genes selected from the group of motX, motY, pomA and pomA/pomB are provided. In addition mutant strains lacking a functional hap gene and/or ctxA gene and/or rtx gene, in combination with one or more of the motX, motY, pomA and pomA/pomB and fliG genes are provided. Mutant strains further comprising alterations wherein expression of the ctxB gene can be induced are also provided. The invention further relates to methods of making genetically engineered mutant V. cholerae strains and to immunogenic compositions thereof. Methods for inducing an immune response by administration of the mutant strains and live or killed cholera vaccines comprising the mutant strains of the invention are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106290850-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9845341-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1493813-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019014462-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011100489-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11484585-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013017218-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7231607-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011100489-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019139468-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111511394-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020527343-A |
| priorityDate |
2000-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |