| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_755f1cd6b460b490c56b6bd50cbc73af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3a2f32729d4ff54ee7d586426c4b73c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4327fb83685f7df6c771311ef9f39076
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fc2a22a9271507062ad7e07974d3c58 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate |
2001-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e6c6734f47c87d18c09ff3eed28210f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb391d4c72372cb3839a977ab656eab0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a52f6fed16b73b8ddf027b208f221e8c |
| publicationDate |
2001-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0166745-A2 |
| titleOfInvention |
Presenilin/crk binding polypeptides (pcbp) and methods of use thereof |
| abstract |
The invention provide Presenilin/Crk binding polypeptides characterized by interacting with Presenilin polypeptides, modulating intracellular calcium mobilization, and redistributing from cytoplasm to membrane in the presence of a Presenilin polypeptide. The Presenilin/Crk binding polypeptides are further characterized by interacting with a Crk polypeptide and by containing at least one SH3 domain. Also provided are isolated nucleic acids encoding Presenilin/Crk binding polypeptides, antibodies that bind to Presenilin/Crk binding polypeptides, expression vectors containing Presenilin/Crk binding polynucleotides and host cells transformed by Presenilin/Crk binding polynucleotides. The invention provides a method for identifying a compound that modulates intracellular calcium mobilization and/or modulates Presenilin/Crk binding protein levels or activity. The invention includes a method of treating a disorder associated with Presenilin/Crk binding protein. Also provided is a method of diagnosis of a subject having or at risk of having a disorder of the nervous system such as Alzheimer's disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1239051-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1239051-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1390501-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1390501-A4 |
| priorityDate |
2000-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |