| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_662717c94dd93edb84c2df5ba0d5e45c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-366
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-287
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-261 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-36 |
| filingDate |
2001-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d66af232ce007944032a117919d0b1a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9654bc22cb275c57e83d1b18ede9dd7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9788b95460cd6079b8a4bf967bb4dfa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_415569e36d1a14243119425d01deb4c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69fe0e858f35fa57105c7fdbcc6b1c81 |
| publicationDate |
2001-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0166218-A1 |
| titleOfInvention |
Chromatographic method for rna stabilization |
| abstract |
The instant invention provides a method for stabilizing an RNA molecule against degradation comprising applying a solution to a separation medium having a non-polar separation surface in the presence of a counterion agent, wherein the solution comprises the RNA molecule and an agent capable of catalyzing the degradation of RNA; eluting the RNA molecule from the separation medium by passing through the separation medium a mobile phase containing a concentration of organic solvent sufficient to elute the RNA molecule from the separation medium, where the elution is conducted under conditions that result in a substantial separation of the RNA molecule from the agent capable of catalyzing the degradation of RNA; and collecting an eluant fraction containing the RNA molecule that is substantially free of the agent capable of catalyzing the degradation of RNA. In a preferred embodiment the method is performed under conditions that are substantially free of multivalent cations. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015140326-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011014357-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6521411-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102770769-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8377394-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017508995-A |
| priorityDate |
2000-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |