| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d129195d35f178edd75fb75e7d8f5fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73beab86ccd37693209558a91b23928c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0db69246a68da9c2413b0ec70f21efe6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97c70d82be413a7912cf669a7388ad3d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0605
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-19 |
| filingDate |
2001-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_333dc5bc95c36a37996d5db3c35fad25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6a4bd96dfa42573db09b08c22d58c26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d35ddbd273707fa429968254cd7505da |
| publicationDate |
2001-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0163281-A1 |
| titleOfInvention |
Methods of screening for compounds that modulate blood vessel formation |
| abstract |
The invention provides a method of screening for agents that promote or inhibit vasculogenesis or angiogenesis. The screening methods comprise culturing mesodermal stem cells, for example, allantoic cells; contacting the mesodermal stem cells with the agent to be screened; detecting endothelial cells or endothelial stem cells in the culture; and comparing the endothelial cells or endothelial cell precursors in the culture to be screened, with the endothelial cells or endothelial cell precursors in a control culture. An increase in endothelial cells or endothelial cell precursors in the culture to be screened indicates an agent that promotes vasculogenesis or angiogenesis. A decrease in endothelial cells or endothelial cell precursors in the culture to be screened indicates an agent that inhibits vasculogenesis or angiogenesis. The present invention also provides a method of screening for an agent that stabilizes vasculature or promotes remodeling of vasculature. The present invention further provides a method of screening for genes involved in promoting or inhibiting neovascularization (i.e, vasculogenesis and/or angiogenesis). The invention further provides methods of using the identified nucleic acids or agents to promote or inhibit vasculogenesis or angiogenesis in a tumor, tissue, organ, or graft. Also provided are methods of preventing and treating neovascular-dependent diseases using agents or nucleic acids identified by the screening methods of the invention. The invention further provides a method of determining whether stem cells of unknown endothelial cell potential can be promoted to differentiate into endothelial cell precursors. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1496878-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8574827-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1563094-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106497863-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03061591-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03086373-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1496878-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106497863-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1563094-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03061591-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005010524-A1 |
| priorityDate |
2000-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |