| abstract |
Use of a compound for the manufacture of a medicament for the treatment of a respiratory disease involving tissue destruction, wherein a compound has an inhibitory activity of greater than 50 % inhibition of MMP1 or MMP2 or MMP8 or MMP9 at less than 100 νM concentration in an enzyme assay and which also downregulates in COPD lung tissue MMP1 or MMP2 or MMP8 or MMP9 to less than 50 % of untreated levels at 100 νM. |