| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b1c735a2c67e58d45933db86ee514b4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-235
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0619 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0793 |
| filingDate |
2001-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6359fcba05b3bc4abfae78e32c4ef06e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d171c131f776affbf0e99d6d545116cc |
| publicationDate |
2001-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0157191-A1 |
| titleOfInvention |
Generation of dopaminergic neurons from human nervous system stem cells |
| abstract |
The present invention relates to methods for generating dopaminergic neurons in vitro from embryonic and adult central nervous system cells. Specifically, these cells are isolated, cultured in vitro and stimulated to differentiate into dopaminergic neurons by down-regulating COUP-TFI and/or COUP-TFII expression or increasing NOT1 expression. These newly generated dopaminergic neurons may serve as an excellent source for cell replacement therapy in neurological disorders in which the dopaminergic system is compromised. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2009280769-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2326333-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008128526-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008128526-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2326333-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011530484-A |
| priorityDate |
2000-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |