| abstract |
The invention relates to a method for detecting a pathological defect in a cell by means of an antibody. According to the invention, an antibody is used which is specific for i) a protein of a Polycomb group complex; ii) a corepressor or a coactivator of a Polycomb group complex; or iii) a Boundary element-binding protein. Preferably the extent of binding of the antibody is compared with a reference value determined for a normal cell of that type. An abnormal concentration of a protein, and hence a different reference value, has been found to be a very good indicator for detecting a pathological defect, such as cancer. |