| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91de968de97f919e20051eac5802df5f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_625e9bb9a0f3d654cec4a1b2f541b11e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f36a068a101b2eafbc7cfaf29735e93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9036144f84ff5b134fe29dbb4f20610d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_292ce87fe8eb2739a5dab14cf321b9c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9fbde6cef530bebe75bb9246332eb0b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-531
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6803 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-531
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 |
| filingDate |
2000-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_174ef21c6817e6e0293f290aaac6af3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_beca73f2575b1d68480d5ab5128a44ab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56ce6131d23fa31492035c21b85edcac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acbc8a4f792b6d0ef824b992863e4b47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14efa10f96c5028d5ec9ee64b9cb3171 |
| publicationDate |
2002-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0150127-A9 |
| titleOfInvention |
Screening using biological target molecules with metal-ion binding sites |
| abstract |
The present invention provides a molecular approach for rapidly and selectively identifying small organic molecule ligands, i.e. compounds, that are capable of interacting with and binding to specific sites on biological target molecules. The methods of the present invention are applicable to any biological target molecule that has or can be manipulated to have a metal ion binding site. A very interesting group of molecules are membrane proteins such as 7TM transmembrane proteins. The methods described herein make it possible to construct and screen libraries of compounds specifically directed against predetermined epitopes on the biological target molecules. The compounds are initially constructed to be bi-functional, i.e. having both a metal ion binding moiety enabling them to bind to a natural or artificial metal ion binding site, and a variable moiety, which is varied chemically to probe for interactions with specific parts of the biological target adjacent to the metal ion binding site. Compounds may subsequently be further modified to bind to the unmodified biological target molecule without help of the bridging metal ion. |
| priorityDate |
1999-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |