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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-245
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filingDate 2000-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_772dfc225f03f2f58cc4c62051433643
publicationDate 2001-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-0146428-A1
titleOfInvention Vaccine strains against infection with pathogenic bacteria
abstract Vaccine strains having high safety and potent antigenicity (immunogenicity) and being efficaciously usable as live vaccines against a number of pathogenic bacteria; and live vaccine compositions containing these vaccine strains. The above vaccine strains against infection with pathogenic bacteria comprise pathogenic bacteria with deletion or decrease in the pathogenicity-expressing function which are prepared by transferring, by homologous recombination, a DNA having substitution of mukFEB operon relating to the temperature sensitivity in colony formation by kanamycin tolerance gene into a strain having deletion of DNA adenine methylase gene relating to the pathogenicity-expressing function of pathogenic bacteria (for example, enteropathogenic Escherichia coli, murine typhoid bacillus, abdominal typhoid bacillus, dysentery bacillus, klebsiella, pasteurella and actinobacillus) to achieve double gene mutation.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7026155-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03056008-A1
priorityDate 1999-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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