| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_19de4dfcbc6dcd74f110059d77269df3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51a0c49e5390c69aa92b87c3a892344c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_79670dc9895ecb2109543e58199e4b3f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-32 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-07 |
| filingDate |
2000-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cc45460af93d0624b0c605e738ac429
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4395c7cd3cb857f29464061a4958145e |
| publicationDate |
2001-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0145639-A2 |
| titleOfInvention |
Methods for protecting against lethal infection with bacillus anthracis |
| abstract |
Methods of inducing an immune response which protects a susceptible animal subject from lethal infection with Bacillus anthracis (B. anthracis) are provided. One method comprises administering an effective amount of wild-type, or preferably a mutated form of, B. anthracis lethal factor (LF) or an immunogenic fragment thereof to the subject. A second method comprises administering an effective amount of a mutated LF protein or an immunogenic fragment of an LF protein and an effective amount of the B. anthracis protective antigen (PA) or an immunogenic fragment of the PA protein to the subject. A third method comprises administering a polynucleotide or nucleic acid comprising a sequence encoding a mutated B. anthracis LF protein or an immunogenic fragment of an LF protein to the subject. A fourth method comprises administering a polynucleotide which comprises a coding sequence for a mutated LF protein or an immunogenic fragment of an LF protein and a polynucleotide which comprises a coding sequence for the B. anthracis PA protein or an immunogenic fragment thereof to the subject. The present invention also relates to a protein or peptide based-immunogenic composition for preparing a vaccine which is capable of prophylactically protecting a subject against lethal effects of infection with B. anthracis or exposure to a toxic agent which is produced by B. anthracis. The protein or peptide based immunogenic composition comprises a purified or recombinant LF protein or immunogenic fragment thereof and a purified or recombinant PA protein or immunogenic fragment thereof. The present invention also relates to a nucleic acid-based immunogenic composition comprising a nucleic acid which comprises a sequence encoding the LF protein or an immunogenic fragment thereof and a polynucleotide which comprises a sequence encoding the PA protein or an immunogenic fragment thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8101735-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1954307-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004098636-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1958960-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03037370-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3067601-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004098636-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1735338-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011110954-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7906119-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7947268-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1735338-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7601351-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03037370-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8409590-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1954307-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8323927-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004087216-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004087216-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03087378-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8440427-B2 |
| priorityDate |
1999-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |