| abstract |
The present invention relates to an arginine-enriched medium composition used for mass-producing recombinant protein in animal cell culture. Particularly, the present invention relates to the arginine-enriched medium composition containing arginine by the concentration of 160-4200 mg/L which corresponds to 2-50 folds of the previously used medium. The arginine-enriched medium composition of the present invention can be widely used for mass-producing the recombinant protein in animal cell culture by preventing the early growth inhibition of cell and increasing the viability and life span of cell. Especially, the arginine-enriched medium composition is effectively used for mass-producing human thrombopoietin (TPO), human erythropoietin (EPO), blood coagulating agent (tPA) and antibody. |