| abstract |
Sphingosine derivatives represented by general formula (I), or pharmaceutically acceptable salts thereof, wherein R?1 and R2¿ are each hydrogen or the like; Z is NR7 (wherein R7 is hydrogen or the like); Y is oxygen or NR8 (wherein R8 is hydrogen or the like); W is oxygen or sulfur; and k is an integer of 1 to 20. The derivatives and the salts are useful as preventive or therapeutic drugs for cerebrovascular disorders such as cerebral hemorrhage and cerebral infarction; head injuries; senile dementia; degenerative diseases of cranial nerve such as Alzheimer disease and Parkinson disease; diabetes; obesity; arteriosclerosis; inflammatory diseases; immunologic diseases; cancers; kidney diseases; and heart diseases. |