| abstract |
Phenylalanine derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof: wherein x represents an interatomic bond, -O-, etc.; Y and Z represent each -C(=O)-, etc.; A represents a specific substituted phenyl group, a specific nitrogen-containing heterocycle, etc.; C represents hydrogen, alkly, etc.; D and E represent each alkyl or D and E may be bonded to each other to form a ring, etc.; F and G represent each hydrogen or alkyl, or F and G may be bonded to each otherto form a ring, etc.; n is from 0 to 2; K represents OR7, NR7R8, R7, etc.; and J and J' represent each hydrogen, halogeno, etc. These derivatives and analogs thereof show an α 4 integlin inhibitory activity and are usable as remedies for various diseases relating to α 4 integlin. |