| abstract |
Nitrogenous heterocycle derivatives of general formula (I), pharmacologically acceptable salts of the same, or esters or other derivatives thereof, having an excellent inhibitory effect on ileal bile acid transporter. In said formula, R?1, R2, R3 and R4¿ are each hydrogen, hydroxyl, or lower alkoxy; R5 is aryl; and R6 is -CONR7R8 (wherein R7 is C¿1-10? alkyl or C2-10 alkenyl; and R?8¿ is aryl or an aromatic heterocyclic group), with the proviso that when R2 is hydrogen and R3 is lower alkoxy, R5 is aryl which is mono- to penta-substituted with hydroxyl and/or lower alkoxy groups. |