| abstract |
The invention relates to a pharmaceutical compositions provided in the form of microemulsion preconcentrates containing: (a) a mixture comprised of a middle chain triglyceride and of an omega-9-fatty acid and/or of an omega-6-fatty acid; (b) a therapeutic active substance which is poorly soluble in water but, however, is soluble in constituent (a) and which is selected from the class of cyclosporines, preferably cyclosporine A, and; (c) a surface active constituent containing a surfactant of the polyoxethylene type; however, containing essentially none of the following constituents which can be mixed with water or which are soluble in water: C1-C5 alkyl diether or tetrahydrofurfuryl diether or partial ether of low-molecular monooxy or polyoxy C2-C12 alkane diols; 1,2-propylene glycol; low alkanols; esterification products or polycarboxylic acids with 2-10, especially 3-5 carboxyl groups with C1-C10 alcohols, and; esterification products of polyols with 2-10, especially 3-5 carboxyl groups with C2-C11 carboxylic acids. These microemulsion preconcentrates form microemulsions when brought into contact with water or with an aqueous medium, whereby those of the O/W type have an average particle size of less than 150 nm, preferably of less than 100 nm. The active substance is solubilized in a stabile manner in these microemulsions. The microemulsion preconcentrates and microemulsions are suited for oral, topical or parenteral administration. |