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filingDate 2000-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2001-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-0125450-A1
titleOfInvention Use of soluble costimulatory factor for tumor immuno-gene therapy
abstract A new gene therapy entails tumor treatment by introducing an expressible nucleotide sequence for a soluble costimulatory factor, thereby enhancing the response of T-cells to a tumor. In vivo expression of the soluble factor overcomes anergy or tolerance to tumor cells and activates T-cells that are infiltrating or surrounding the tumor. A pharmaceutical composition containing such a gene is effective in tumor suppression.
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