abstract |
This invention relates to newly identified colon and colon cancer related polynucleotides as well as the polypeptides encoded by these polynucleotides known collectively herein as "colon cancer antigens", as well as the use of these cancer antigens of the colon to target specific types of cells and / or to diagnose, detect, prevent and treat disorders of the colon, in particular the presence of colon cancer and metastases of colon cancer. This invention relates to colon cancer antigens as well as vectors, host cells, antibodies to colon cancer antigens, and recombinant or synthetic methods for their production. The invention also relates to diagnostic methods for diagnosing and treating, preventing and / or prognosis of colon disorders, including colon cancer, and therapeutic methods of treating these disorders. In addition, the invention relates to screening methods for identifying agonists as well as antagonists of colon cancer antigens of the invention. Furthermore, the invention relates to inhibiting the production and function of the polypeptides of the present invention. |