| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e1018b924ad1e238642eaad9d2172a7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-635 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 |
| filingDate |
2000-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51a0bfc3b64cf9bddc6dc3dd33820abf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3285a14417a4e2a7c7a18d19a8e6f31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae9c7e4f75953b00f5f1941e1e2527c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ace53f4adb2c38e5dece99873131af08 |
| publicationDate |
2001-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0121643-A2 |
| titleOfInvention |
Parathyroid hormone analogues for the treatment of osteoporosis |
| abstract |
The invention disclosed relates to analogues of human parathyroid hormone (hPTH) which have increased activites in bone restoration, and increased bioavailabilities. The analogues described are either single cyclic (1-28) or (1-29) analogues, or double cyclic (1-28) to (1-31) analogues. The single cyclic analogues are cyclised between amino acid pairs R22 and R26. The double cyclic analogues are cyclised between amino acid pairs 13 and 17, and 22 and 26. Various substitutions of the natural residues for other amino acids are also described. For example, the natural Lys27 residue may be substituted by Leu. Typically, these novel analogues have enhanced abilities to stimulate adenyl cyclase activity in rat osteosarcoma cells, and show increased activities in bone restoration using the ovariectomized rat model. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7820179-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008016404-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011032282-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008016404-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8563513-B2 |
| priorityDate |
1999-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |