| abstract |
Compounds of formula (I), where preferably: A = a bridge of partial formula (II) or (III), R?1 and R2¿ = independently (substituted) alkyl, aryl or aralkyl, or together form a heterocycle, R3 = H, -CO-Alkyl, or -CO-Aryl, R4 = Aryl,-CO-O-Aryl or -CO-Aryl and R5 = H, are potent inhibitors of NO-synthase and are suitable as pharmaceutical agents for prophylaxis and treatment of disease states associated with a disturbed NO metabolism. |