| abstract |
The present invention provides methods of treating a mammal, such as a mammal suffering from benign prostate hyperplasia, prophylactically or therapeutically. The methods comprise administering a prophylactic or therapeutic nucleic acid operably linked to a promoter to a mammal in need of prophylactic or therapeutic treament of its prostate via transurethral injection, the use of a prostate-specific promoter and/or the use of a targeting moiety that preferentially binds to a prostate cell, instead of a non-prostate cell, whereupon the prophylactic or therapeutic nucleic acid is expressed in cells of the prostate of the mammal, thereby prophylactically or therapeutically treating the mammal. |