| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bc5292a07e34d16eb1d033a16d3aec3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 |
| filingDate |
2000-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75fa611af9a0383e94f43ac0dd2a11c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a706d0a4f2ff11d5da92a6825e78c27a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_704ef8c80a19552f9710fae08fcefa21 |
| publicationDate |
2001-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0121197-A1 |
| titleOfInvention |
Synthesis of insulin derivatives |
| abstract |
A method for the 'one-pot' synthesis of insulin derivatives wherein insulin is modified at the α-amino group of the PheB1 residue is described. The method comprises protecting the α-amino group of the GlyA1 residue and the ε-amino group of the LysB29 residue by reaction of insulin with a cyclic anhydride of a dicarboxylic acid in the presence of a tertiary amine. The protected insulin is then reacted with an activated hydrophilic compound, preferably an activated polynthylene glycol, resulting in a conjugate of the hydrophilic compound coupled to the PheB1 residue of insulin. The protecting groups are then removed from the conjugate under mild acidic conditions, and the resulting insulin derivative can be purified by conventional methods. Monosubstituted insulin derivatives wherein polyethylene glycol or derivatives thereof or glycosides are couple to the PheB1 residue of insulin are also described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9682153-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2090323-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NO-340825-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006135930-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010033220-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006135930-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010033220-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014160185-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7879588-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8450097-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1773878-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1773878-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02098232-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1404178-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1404178-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03022996-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006014673-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101309770-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2527893-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101276754-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2093235-A1 |
| priorityDate |
1999-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |