| abstract |
The invention relates to magnetic nanoparticles, to the production thereof and to their use. The aim of the invention is to prepare nanoparticles which, also in the intracellular area of cells, can specifically bond to intracellular biomacromolecules so that a separation is made possible by the action of an external magnetic field. This is achieved by using magnetic nanoparticles which have a biochemical activity and which are comprised of a magnetic nuclear particle and of a shell layer that is fixed to the nuclear particle. The nanoparticles contain a compound of general formula M - S - L - Z (I), whereby the binding sites between S and L and L and Z have covalently bound functional groups. M represents the magnetic nuclear particle, S represents a biocompatible substrate fixed to M, L represents a linker grouping, and Z represents a grouping, which is comprised of nucleic acids, peptides or proteins or of their derivatives, and which has at least one structure that is specifically capable of binding with a binding domain of an intracellular biomacromolecule. |