| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3873abaff397acbfffa1595a12cfef41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_98d9d73d6114f7630c6e348a4dbeca70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3f43dec428ed5ae9e562dacae5f4fec5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be10bda9b9af0890d4597d47ec1acda3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_13d3cc8e302a0d7aa286119c208a790e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2000-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ec6c6ec51b5991cdc2f8b2ede0f6a20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef300b63284dce136f621621d3aa2c8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44da6ce954075c31fb6e76811e7fb65d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3adeed59928f9f66f3bdb04522bc4f6 |
| publicationDate |
2001-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0118544-A1 |
| titleOfInvention |
Diagnosis, prognosis and treatment of trinucleotide repeat-associated diseases and intranuclear inclusions-associated diseases |
| abstract |
The present invention relates to a method for the diagnosis of a disease associated with protein accumulation in intranuclear inclusions in a cell of a patient. The method comprises obtaining a sample from the patient; and determining a presence of the protein accumulation in the intranuclear inclusions, wherein the protein accumulation in the intranuclear inclusions is indicative of a disease associated therewith. The invention also relates to a method for the screening of agents which can module one of (a) polyamino acid stretch-containing protein expression; (b) accumulation of polyamino acid stretch-containing proteins in intranuclear inclusions; and (c) toxicity of polyamino acid stretch-containing proteins to cells, which comprises incubating a cell which expresses a polyamino acid stretch-containing protein, associated with a disease or condition in an animal, with a compound; and assessing one of (a) to (c); whereby a modulator is selected when the agent significantly modulates one of the expression, accumulation and toxicity, as compared to a control agent. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006105038-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03020977-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006105038-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2442881-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03020977-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2442881-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104185640-A |
| priorityDate |
1999-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |