| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15d42f684941d5b0617ca7764ebdff07 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-42 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 |
| filingDate |
2000-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c0a327f2317a3d1adf526859622eda9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5d7636a7d6756d3d4ed297cc4a9d7f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6572beff9b665c93041def893d84c331 |
| publicationDate |
2001-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0118224-A1 |
| titleOfInvention |
Adenoviral vectors modified for increased and persistent expression of the cystic fibrosis transmembrane conductance regulator gene in human airway epithelia |
| abstract |
Disclosed are recombinant viral vectors for gene transfer to the epithelium of patients. Preferred embodiments include adenoviral vectors designed for the efficient transfer of the DNA encoding the cystic fibrosis transmembrane conductance regulator (CFTR) to human airways in vivo. The present invention provides vectors for the enhanced expression and persistence of a gene such as CFTR, which may allow lower vector doses and/or longer intervals between readministration and which comprise, in operable linkage, the keratin 18 (K18) promoter/enhanier element, an intron, the transgene and a stability enhancing element. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0206502-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0206502-A2 |
| priorityDate |
1999-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |