| abstract |
Disclosed are novel, selective estrogens type having a steroid skeleton with a non-aromatic A-ring and a free or capped hydroxyl group at carbon atom No. 3. The estrogens satisfy general formula (I), in which R1 is H, (C¿1?-C3)alkyl or (C2-C3)acyl; R?2¿ is H, α-(C¿1?-C4)alkyl, α-(C2-C4)alkenyl or α-(C2-C4)alkynyl; R?3¿ is H or (C¿1?-C4)alkyl, (C2-C4)alkenyl or (C2-C4)alkynyl, each at location 15 or 16 of the steroid skeleton; R?4¿ is H or (C¿1?-C5)alkyl, (C2-C5)alkenyl or (C2-C5)alkynyl, each optionally substituted with halogen; preferred is ethynyl; R?5¿ is H, (C¿1?-C3)alkyl or (C2-C3)acyl; R?6¿ is (C¿1?-C5)alkyl, (C2-C5)alkenyl, (C2-C5)alkynyl or (C1-C5)alkylidene, each optionally substituted with halogen or (C1-C3)alkyloxy; dotted bonds represent optional double bonds. |