| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48ede97bd7aa75a5939da01094fa3f13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50476c050033c07d89a2e56dc34968c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2b9dc89cc4ba060cc73bbf0c90bbb78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_63a722300d346ffc9fa3b539cc4c37cd |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-60 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-60 |
| filingDate |
2000-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9622f9d8c2f6f39df85b9057295e57e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66f3cac52721cb3d6ba968d0001f4f3f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_766513528efb1ceda8d634a696662be8 |
| publicationDate |
2001-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0117966-A1 |
| titleOfInvention |
Process for the preparation of 1-methyl-3-carbomethoxy-4-(4'-fluorophenyl)-piperidine |
| abstract |
A compound of formula (2) is prepared by treating a dispersion of crystalline arecoline hydrobromide in an organic solvent with an anhydrous strongly basic reagent to generate a solution of arecoline free base, which is reacted directly with an organometallic compound of formula (5) in which M is a Group II metal and Y a halogen or the group (I). The compound of formula (5) is typically a Grignard reagent in which M is Mg and Y is Cl or Br. The piperidine ester of structure (2) is reduced to a piperidine carbinol, coupled with sesamol, then deprotected, to give paroxetine. The process avoids the direct handling of the irritant alkaloid oil arecoline. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7138523-B2 |
| priorityDate |
1999-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |