| abstract |
Substituted benzylthiazolidine-2,4-dione derivatives capable of, as a ligand of human peroxisome proliferator-activated receptor (PPAR), enhancing the transcriptional activity of the receptor and showing effects of lowering blood sugar level and lowering lipid level; and a process for producing the same. Substituted benzylthiazolidine-2,4-dione derivatives represented by general formula (1), pharmaceutically acceptable salts thereof and hydrates of the same, wherein R1 represents chloro, bromo, nitro, trifluoromethoxy, ethoxy, propoxy or isopropoxy; and R2 represents hydrogen or chloro. |