| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f47c750954e13a1ed0be96c1bf1c51c7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-346
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3183
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-121 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 |
| filingDate |
2000-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de2e6ec4b76d0cc3197397973a621afb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81faeaa2980cdbdb9d9b6db84807f7d8 |
| publicationDate |
2001-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0112787-A2 |
| titleOfInvention |
Chimeric dna/rna ribozymes containing propanediol |
| abstract |
DNA-RNA-(Pr)n-RNA-DNA ribozymes of formula (III) 5' Z-cugaugag-(Pr)n-cgaaa-X 3'; or (IV) 3'X-aaagc-(Pr)n-gaguaguc-Z-R-Z-cugaugag-(Pr)n-cgaaa-X 3' in which X and Z comprise DNA sequences that base pair with an RNA substrate at positions adjacent to an RNA cleavage site; cugaugag and cgaaa are catalytic RNA sequences; Pr is a spacer residue -P(O) (OH)-O-CH2CH2CH2-O-; and R is a bridging residue of -O-CH2-C(CH2OH) (CH3)-CH2-O-. The ribozymes can be made on any DNA synthesizer using phosphoramidite chemistry, and are useful as therapeutic agents for treating viral or endogenous RNA-mediated diseases. Preferred ribozymes target a sequence in the U5 region of HIV-1. |
| priorityDate |
1999-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |