| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e04826845acea4cc4cdeafc4c2b1e313
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c22ba7d7d37eaa1000835be8cb2737c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-683 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-683
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2000-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7025b7f5c9d4e8def0284fcb22adfe81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e50b034da6297fee5bd1f1c81a95522 |
| publicationDate |
2001-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0105800-A2 |
| titleOfInvention |
A method for the enrichment of heteroduplexes and its use in mutation detection |
| abstract |
A method for selectively enriching heteroduplexes from a mixture of hetero- and homoduplexes comprising binding selectively said heteroduplexes to a heteroduplex binding protein thereby forming a complex between the heteroduplex and the protein. The method is characterized in that the protein is a modified form of a wild-type resolvase, which modified form in comparison to the wild type resolvase retains an ability to selectively bind to heteroduplexes, and has a modified ability to cleave heteroduplexes. In case one of the nucleic strands in the heteroduplexes derives from a sample and the other is a standard nucleic acid strand, the method may be used for detecting mismatches in the sample nucleic acid relative the standard nucleic acid. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9279146-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014096126-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016539624-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7851158-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015078831-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2102365-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016508713-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2102365-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9873908-B2 |
| priorityDate |
1999-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |