| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a52355ecd07cd3e84973ba00406c6482
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f33cb4a8cd82354163b7b308e4dfde5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6a8ad105fd8d0aaeba16dda7b098b5a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ad66884a6f2a66126d492e56e09be39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7ae7cb1494bb620f1fd671c297a7a3e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5079 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
| filingDate |
2000-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1673e534cde3350d679de25ec6af5114
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18baa8dc4d0842be9a9aafa136d51e58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c45492a7e580650c76e968e00be9d9c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a96df7d343a2c31e5946773d5b9ae67e |
| publicationDate |
2001-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0102598-A2 |
| titleOfInvention |
Screening for compounds modulating mitochondrial proton leak |
| abstract |
The present invention provides a screening method for the identification of compounds which modulate an AMP-sensitive regulatory site on mitochondria comprising the steps of: a) contacting a test compound with mitochondria in the presence of a substrate for respiration in the presence of a buffer system; b) measuring an index of metabolic rate; and c) identifying compounds which modulate metabolic rate. Alternatively or additionally membrane potential can be measured. The invention also comprises a regulatory site for a mitochondrial proton leak which is related to the adenine nucleotide carrier, a binding assay and a functional assay. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007082309-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110791475-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007082309-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9588104-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8633017-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0185944-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6509167-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6495337-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7214503-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8265357-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0185944-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110791475-B |
| priorityDate |
1999-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |