| abstract |
Heterocyclic compounds represented by the following general formula which have inhibitory effects on AP-1 activity, NF-Kappa B activity, inflammatory cytokine production, matrix metalloprotease production, inflammatory cell adhesion factor expression, etc. and are usable as drugs: R1-C(=O)-N(R2)-A-X-B-N(R3)-Y-(CH¿2)n-R?4 wherein R1 represents cycloalkyl or cycloalkenyl; R?2 and R3¿ represent each hydrogen or alkyl; R4 represents alkyl, a heterocycle, etc.; n is an integer of from 0 to 6; A represents a heterocycle; B represents an aromatic ring or a heterocycle; and X and Y represent each a bond or a linking group. |